Thursday, 29 September 2016

Deuterium Labeled Compound


Used as internal standard for method validation in Bioanalytical Studies.

http://www.vivanls.com/deuterium-labeled-compounds

These come under stable labelled Isotopes

Deuteration has no effect on biological potency or selectivity

Potential for drug to have longer half life and reduced/less frequent dosing

Improve metabolite profile : prevent formation of toxic Metabolites

Example : (+/-)-4-Hydroxy Propranolol-d7 Hydrochloride

It is a labelled metabolite of Propanolol

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